The Common LDLR p.G116S Variant Has a Large Effect on Plasma LDL Cholesterol in Circumpolar Inuit Populations
نویسندگان
چکیده
Robarts Research Institute, Department of Medicine, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada; The Center for Alaska Native Health Research, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK; The Dalla Lana School of Public Health, University of Toronto; The Keenan Research Centre for Biomedical Science of St. Michael's Hospital & University of Toronto, Toronto, ON, Canada; Axe Santé des populations et pratiques optimales en santé, Centre de Recherche du CHU de Québec & Département de médecine sociale et préventive, Université Laval, QC, Canada; The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark †deceased
منابع مشابه
Common low-density lipoprotein receptor p.G116S variant has a large effect on plasma low-density lipoprotein cholesterol in circumpolar inuit populations.
BACKGROUND Inuit are considered to be vulnerable to cardiovascular disease because their lifestyles are becoming more Westernized. During sequence analysis of Inuit individuals at extremes of lipid traits, we identified 2 nonsynonymous variants in low-density lipoprotein receptor (LDLR), namely p.G116S and p.R730W. METHODS AND RESULTS Genotyping these variants in 3324 Inuit from Alaska, Canad...
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